Type 1 diabetes is an autoimmune disorder in which the body’s immune system destroys insulin-producing beta cells in the pancreas, leading to absolute insulin deficiency and lifelong dependence on exogenous insulin therapy. Unlike its polygenic counterpart type 2 diabetes, type 1 disease exhibits strong genetic susceptibility concentrated in the major histocompatibility complex on chromosome 6, particularly the HLA class II region, alongside contributions from over 60 additional non-HLA loci that modulate immune regulation and beta cell function.
For researchers and clinicians working at the intersection of genomics and …
